The Karner Laboratory

The amino acid sensor Eif2ak4/GCN2 is required for proliferation of osteoblast progenitors in mice.

Hu G, Yu Y, Tang YJ, Wu C, Long F, Karner CM.

J Bone Miner Res. 2020 May 26;. doi:10.1002/jbmr.4091. PMID: 32453500

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Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells.

Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, HIlton MJ and Karner CM.

Cell Metabolism. 2019

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Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.

Karner CM, Esen E, Okunade AL, Patterson BW and Long F.

J Clin Investigation. 2015 Feb;125(2):551-62.  PMID 25562323

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Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation.

Karner CM, Esen E, Chen J, Hsu FF, Turk J and Long F.

J Biol Chem. 2016 Jun 17;291(25):13028-39. PMID:27129247

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Dual function of BMPr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse.

Lim J, Shi Y, Karner CM, Lee SY, Lee WC, He G and Long F. 

Development. 2016 Jan 15;143(2):339-47. PMID:26657771

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Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

Karner CM, Long F, Solnica-Krezel L, Monk KR and Gray RS. 

Hum Mol Genet. 2015 Aug 1;24(15):4365-73. PMID:25954032

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WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

Esen E, Chen J, Karner CM, Okunade AL, Patterson BW, Long F.

Cell Metab. 2013 May 7;17(5):745-55. doi: 10.1016/j.cmet.2013.03.017. Epub 2013 Apr 25.PMID:23623748

 

Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.

Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G.

Nat Genet. 2012 Dec;44(12):1382-7. doi: 10.1038/ng.2452. Epub 2012 Nov 11.PMID:23143599

 

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ.

Development. 2011 Apr;138(7):1247-57. doi: 10.1242/dev.057646. Epub 2011 Feb 24.PMID:21350016

 

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.

PLoS One. 2010 Apr 29;5(4):e10418. doi: 10.1371/journal.pone.0010418. PMID:20454682

 

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ.

Nat Genet. 2009 Jul;41(7):793-9. doi: 10.1038/ng.400. Epub 2009 Jun 21.PMID: 19543268

Selected Publications

 

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