The Karner Laboratory

Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells.

Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, HIlton MJ and Karner CM.

Cell Metabolism. 2019

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BMP induces osteoblast differentiation through both Smad4 and mTORC1 signaling.

Karner CM, Lee SY and Long F.

Mol and Cell Biol. 2017 Feb1;37(4). pii: e00253-16. PMID:27920253

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Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation.

Karner CM, Esen E, Chen J, Hsu FF, Turk J and Long F.

J Biol Chem. 2016 Jun 17;291(25):13028-39. PMID:27129247

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Dual function of BMPr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse.

Lim J, Shi Y, Karner CM, Lee SY, Lee WC, He G and Long F. 

Development. 2016 Jan 15;143(2):339-47. PMID:26657771

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Wnt4 is essential to normal mammalian lung development.

Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ and Cleaver O. 

Dev Biol. 2015 Oct 15;406(2):222-34. PMID:26321050

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Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

Karner CM, Long F, Solnica-Krezel L, Monk KR and Gray RS. 

Hum Mol Genet. 2015 Aug 1;24(15):4365-73. PMID:25954032

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Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.

Karner CM, Esen E, Okunade AL, Patterson BW and Long F.

J Clin Investigation. 2015 Feb;125(2):551-62.  PMID 25562323

 

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.

Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ.Nat Cell Biol. 2013 Sep;15(9):1035-44. doi: 10.1038/ncb2828. Epub 2013 Aug 25. Erratum in: Nat Cell Biol. 2013 Oct;15(10):1260. PMID: 23974041

 

WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

Esen E, Chen J, Karner CM, Okunade AL, Patterson BW, Long F.

Cell Metab. 2013 May 7;17(5):745-55. doi: 10.1016/j.cmet.2013.03.017. Epub 2013 Apr 25.PMID:23623748

 

Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.

Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G.

Nat Genet. 2012 Dec;44(12):1382-7. doi: 10.1038/ng.2452. Epub 2012 Nov 11.PMID:23143599

 

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F.

PLoS Genet. 2012;8(3):e1002577. doi: 10.1371/journal.pgen.1002577. Epub 2012 Mar 22.PMID:22457635

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Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ.

Development. 2011 Apr;138(7):1247-57. doi: 10.1242/dev.057646. Epub 2011 Feb 24.PMID:21350016

 

Tankyrase is necessary for canonical Wnt signaling during kidney development.

Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ.

Dev Dyn. 2010 Jul;239(7):2014-23. doi: 10.1002/dvdy.22340.PMID:20549720

 

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.

PLoS One. 2010 Apr 29;5(4):e10418. doi: 10.1371/journal.pone.0010418. PMID:20454682

 

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ.

Nat Genet. 2009 Jul;41(7):793-9. doi: 10.1038/ng.400. Epub 2009 Jun 21.PMID: 19543268

Selected Publications

 

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