Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation.

Shen L*, Sharma D*, Yu Y, Long F, Karner CM.

Journal of Cell Science. 2021 Jan 11;134(1);jcs251645.  PMID: 33262314

The amino acid sensor Eif2ak4/GCN2 is required for proliferation of osteoblast progenitors in mice.

Hu G, Yu Y, Tang YJ, Wu C, Long F, Karner CM.

J Bone Miner Res. 2020 May 26;. doi:10.1002/jbmr.4091. PMID: 32453500

Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells.

Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, HIlton MJ and Karner CM.

Cell Metabolism. 2019

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.

Karner CM, Esen E, Okunade AL, Patterson BW and Long F.

J Clin Investigation. 2015 Feb;125(2):551-62.  PMID 25562323

Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation.

Karner CM, Esen E, Chen J, Hsu FF, Turk J and Long F.

J Biol Chem. 2016 Jun 17;291(25):13028-39. PMID:27129247

Dual function of BMPr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse.

Lim J, Shi Y, Karner CM, Lee SY, Lee WC, He G and Long F. 

Development. 2016 Jan 15;143(2):339-47. PMID:26657771

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

Karner CM, Long F, Solnica-Krezel L, Monk KR and Gray RS. 

Hum Mol Genet. 2015 Aug 1;24(15):4365-73. PMID:25954032

WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

Esen E, Chen J, Karner CM, Okunade AL, Patterson BW, Long F.

Cell Metab. 2013 May 7;17(5):745-55. doi: 10.1016/j.cmet.2013.03.017. Epub 2013 Apr 25.PMID:23623748


Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.

Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G.

Nat Genet. 2012 Dec;44(12):1382-7. doi: 10.1038/ng.2452. Epub 2012 Nov 11.PMID:23143599


Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ.

Development. 2011 Apr;138(7):1247-57. doi: 10.1242/dev.057646. Epub 2011 Feb 24.PMID:21350016


Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J.

PLoS One. 2010 Apr 29;5(4):e10418. doi: 10.1371/journal.pone.0010418. PMID:20454682


Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ.

Nat Genet. 2009 Jul;41(7):793-9. doi: 10.1038/ng.400. Epub 2009 Jun 21.PMID: 19543268

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